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KMID : 0606320060230010046
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Journal of Phamacetical Sciences Sookmyung Women s University
2006 Volume.23 No. 1 p.46 ~ p.49
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Preparation of Temperature-Sensitive Liposomes Using Differential Scanning Calorimetry
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Kim Jin-Seok
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Abstract
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New temperature-sensative liposomes, which show a transition temperature around 41 ℃, were prepared using a differential scanning calorimetry method. Various compositions of phospholipids with or without encapsulated drug were tested and DPPC:DMPC:DSPC (4:1:1 molar ratio) liposome was found to have a transition temperature of 41 ℃ from solid gel state to liquid crystalline state, which might be useful for targeting of anticancer drugs or radio-sensitizers to the tumor or inflammation sites.
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